Non-clinical CRO

Non-clinical CRO

Lab Animal Center

AAALAC & Korean Excellent Animal Research Facility (KELAF) Accredited With internationally compliant animal management programs and cutting-edge facilities, we offer shared laboratory spaces and ensure reliable research outcomes.

Kolmar BioTech Lab Animal Center's Key Offerings

Under IACUC* supervision, the center offers cutting-edge animal housing and laboratory rental services, supported by a scientifically managed animal care program.


  • 01

    1st AAALAC-Accredited Animal Facility Operated by Private Company in Korea

    Facilitate IND filing to U.S. FDA or the European Medicines Agency.

  • 02

    Korean Excellent Animal Research Facility(KELAF) Certified

    Accredited for meeting the standards in personnel, facilities, operations, and programs required for the use and care of laboratory animals.

  • 03

    In-house IACUC

    Conducting internationally validated review process for animal research protocols and providing administrative support necessary for research.

*IACUC(Institutional Animal Care and Use Committee)


Main Services

Scientific laboratory animal care management under the supervision of internal IACUC.
State-of-the-art animal room & laboratory rental services

Service that secures and offers experimental subjects through natural mating or IVF of genetically modified mice.
= Colony Expansion Service.

  • Disease Animal Model Creation and Dosing
  • Dosing Methods
    (intraperitoneal, oral, subcutaneous, intradermal, venous, intratracheal, spinal, intracerebral)
  • Blood Collection
    (Cardiac, Retro-Orbital plexu, jugular vein, abdominal aorta, posterior vein, tail vein, facial vein)
  • Necropsy

  • Location

    kolmar BioCluster for New Drug Development, Floor B4 - B5

  • Size

    2,800m² , 10,000 Cages

  • Species

    Mouse, Rat

  • Accreditations

    Ministry of Food and Drug Safety,
    Excellent Animal Research Facility
    (No. 18, designated July 31, 2020)

    AAALAC Accreditation
    (Reacquired in June 2025)

  • Key Facilities

    BL2 SPF animal space

    Behavioral observation room, Imaging room, Isolation room etc.

  • Operating Hours

    24/7 year-round
    (Please inquire in advance for access outside of regular working hours)

Vivashare (Animal Research Laboratory)

We uphold the highest standards of laboratory animal care and management, supported by TECNIPLAST's advanced equipment and Interceptor inspection, as well as QM Diagnostics' state-of-the-art health monitoring services. As a partner of the International Experimental Animal Association, QM Diagnostics' services are exceptionally high in quality and reliability. Our unwavering objective is to ensure the optimal health and well-being of the laboratory animals under our care.


  • 10,000+ Cages
  • 4 Change-Station available for free use in the housing room
  • Shared laboratory available by reservation
  • No. of entry: 2 person
  • Standard housing allows up to 5 animals per cage
  • For HFD studies, no more than 3 animals per cage are recommended
  • Rats are recommended to be housed at 2 animals per cage
Equipment

DVC
GM500
+EM500


Basic Services Provided

Service Details
  • PPE(Disposable): Dustproof suit, Hair cap, Mask, Gloves, Overshoes
  • Disinfectant, Hand towel
  • Experimental articles cabinet
  • Ice, LN2
  • O2 gas
  • CO2 euthanasia chamber
  • Medical waste disposal facilities
  • Locker room, Shower room
  • Rest area and Meeting space
  • 365 days, 24/7 Free access anytime
  • Online education, Service application
  • Laboratory Animal Procurement Service
  • Shared office space

Laboratory Animal Management Program

In partnership with QM Diagnostics, a 45-year leader in animal diagnostics, we assess infection status in mice through non-sacrificial methods.

Breeding Room(Animal Housing Room)
Items Details
Air Handling Method Heating Ventilation Unit (HVU)
Temperature 20 - 26 º C
Humidity 30 - 70 %
Ventilation 8 - 15 / 1 hour
Illumination 12 h : 12 h (7:00 on, 19:00 off), 150 - 300 Lux
Cage
Item Details
Type/Manufacturer Individually Ventilated Cage (IVC) /
Tecniplast
Model Mouse Rat
GM500 EM500 1145T 1291H
Floor Area 501 ㎠ 512 ㎠ 453 ㎠ 800 ㎠
Head* 5 5 4 3
Ventilation Rate 75 Ventilation Rate 75 Ventilation Rate 75 Ventilation Rate 75 Ventilation Rate

*Mouse ≥ 25g , Rat ≥ 300g

Breeding Management
Management Items Details
Feed R3+ (for maintenance) SAFE A30 (for breeding)
Feed Supply System Free ingestion
Water Supply Reverse Osmosis (RO) distilled water
Water Supply System Automatic water supply or bottle
Bedding ASPEN
Enrichment S-brick, M-brick, Cube, Igloo, Tunnel, Nestlets, Happi mat
Hygiene Management
  • Feed, bottle : Daily check, Replacement every once a week
  • Bedding :

    Mouse - Replace once every 1 weeks
    Rat - Replace once every 1 weeks

  • Filter top, wire mesh : Replace once a month
Sterilization Verification
  • Bowie Dick test
  • BI (Dry & Wet type)
  • CI
Environmental Disinfection Disinfectant change every month (Bromcept, VirkonS, Chlorine bleach)

Breeding Lab

A service with state-of-the-art equipment and innovative management programs


  • Mouse Strain recovery
    (IVF-ET)

    Applicable to laboratory animals infected with pathogenic microorganisms, including transgenic (TG) and knockout (KO) and KnockIn (KI) mice

    Ensures SPF (Specific Pathogen-Free) con ditions and reproducibility of experiments by restoring breeding lines through embryo transfer

  • Genotyping (PCR Analysis)

    Maintains genetic consistency in laboratory mice during colony maintenance

    Minimizes experimental variability and en sures consistent, reliable research outcomes

  • Mouse Colony Maintenance and Breeding

    Capable of large-scale production of genetically engineered mice (GEM)

    Enables cost-effective and consistent supply of laboratory animal


Major Facilities and Equipment

Germ-Free
Microbiome Experiments
  • Examine mechanisms of microorganisms or derived materials
  • Breeding management know-how to maintain aseptic conditions and
    integration of advanced equipment

IVIS Lumina 5X™ In vivo Imaging System
  • Imaging of fluorescent or luminescent signals labeled in cells or drugs
  • Evaluation of anticancer candidates, Confirmation of distribution of cell therapy agents

Raji-Luc Xenograft Mode (IVIS Test Example)
G1
G2
Drug Distribution Study (IVIS Test Example)
fluorescence

Insight Bone Density & Body Composition Analysis
  • DEXA equipment with x-ray principles
  • Used for experiments with osteoarthritis and
    metabolic disorders(e.g. ob

Metabolic Disorders and Musculoskeletal Diseases Study (DEXA Test Example)
X-ray

Home-Cage Activity Analysis
  • 24 hours of continuous activity data collection
  • Evaluation of candidate substances for the treatment of degenerative brain diseases
  • Initial safety screening of new drug candidates

Microbial / Environmental Monitoring

Test Item Description
Cell Line Test Heating Ventilation Unit (HVU)
Laboratory
Animal Testing
20 - 26 ºC
Health Monitoring Quarterly Sentinel animal testing
Environmental Monitoring Temperature and humidity, air quality, lighting, noise, drinking water, feed, airborne bacteria

Health Monitoring

Items Frequency Testing Method Agency
Breeding Rooms Maximum 3 months Sentinel animal testing exposed to Soiled bedding QM diagnostics
Other Housing Rooms High+ 3 months Sentinel animal testing exposed to Soiled bedding
Environmental Monitoring 3 months Illumination, temperature, humidity, noise, Microbial monitoring Self-inspection

* Based on the section on standardizing health monitoring items for mice and rats in the Handbook of Health Monitoring for Laboratory Rodents, jointly published by the Korea Mouse Phenotyping Consortium (KMPC) and the Korean Society of Laboratory Animal Medicine (KCLAM).


Kolmar BioTech partners up with QM diagnostics, the world's
leading diagnostic company specialized in laboratory animals.

QM diagnostic is a 45-year-old European diagnostic testing company
specializing in laboratory animals.


QM Accreditation

  • ICLAS ANIMAL QUALITY NETWORK
    It is registered with the International Council for Laboratory Animal Science (ICLAS) Animal Quality Network.
    (The Jaxon Lab and Charles River Lab are also registered.)
  • ISO 17025 Accreditation
    QM Diagnostics has been granted accreditation based on ISO/IEC 17025:2017 with registration number L606.
    ISO/IEC 17025:2017 specifies the general requirements for the competence, impartiality, and consistent operation of laboratories

Service

  • Health monitoring
    Particular rodents used for biomedical research.
  • Environmental monitoring
    EAD Test(INTERCEPTOR®), Drinking water quality test

Carry-on Animal & Immunodeficiency Mouse

✓ Infection status can be checked without sacrificing the mouse (Excluding Pneumocysits carinii)
✓ Inspection is possible with small samples

Health Monitoring Items for Experimental Animals (KMPC & KCLAM Recommendations)

Maximum Level
Virus Bacteria Parasites
K-virus
Lactic dehydrogenase virus
Minute virus of mice
Mouse adenovirus (FL, K87)
Mouse cytomegalovirus
Mouse parvovirus
Mouse thymic virus
Pneumonia virus of mice
Polyoma virus
Reovirus 3
Rotavirus (EDIM)
Theiler’s murine encephalomyelitis virus
Bordetella bronchiseptica
Filobacterium rodentium (CAR bacillus)
Staphylococcus aureus
Streptobacillus moniliformis
Fungi
Dermatophytes
Encephalitozoon cuniculi
High Level
Virus Bacteria Parasites
Ectromelia virus
Hanta virus
Lymphocytic choriomeningitis virus
Mouse hepatitis virus
Murine norovirus
Sendai virus
CAP bacillus
Citrobacter rodentium
Clostridium piliforme
Corynebacterium bovis
Corynebacterium kutscheri
Helicobacter billis
Helicobacter hepaticus
Helicobacter typhlonius
Klebsiella pneumoniae
Klebsiella oxytoca
Mycoplasma pulmonis
Rodentibacter heylii
Rodentibacter pneumotropicus
Pseudomonas aeruginosa
Salmonella spp.
Streptococci β-hemolytic
Streptococcus pneumoniae
Ectoparasites
Pinworms
Intestinal Protozoa
Fungi
Pneumocystis murina

Animal Modeling Service

+more
  • Disease Animal Model Creation and Dosing

  • Dosing Methods

  • Blood Collection

  • Necropsy

Non-clinical CRO crowise@kolmarbiotech.com
031-280-5200

LAB CLOUD labcloud@kolmarbiotech.com
031-280-5375

E&C enc@kolmarbiotech.com
031-280-5280